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The acromioclavicular joint includes the clavicleand acromion process of the scapula.

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UCP proteins reduce innermembrane potential through dispersion of protein gradient over mitochondrial membrane andso mitochondrial production of reactive oxygen species is decreased. N Engl J Med, 319 (5): 267–273.Steffen, L.M., Jacobs, D.R. Bouma GJ, Muizelaar JP, Bandoh K, et al: Blood pressure and intracranial pressure-volume dynam-ics in severe head injury: relationship with cerebral blood flow

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I want the Earth to be a better place for my having walked here

I am lucky to have been born in Philadelphia, United States in the twentieth century when women are not worth less than cows and universities believe everyone who strives is entitled to an education. Born in a working class neighborhood where men hit their wives and we children roamed the neighborhood unattended in dirty-footed clusters, people and institutions leaned in. Brown University offered a financial package and wings; MIT honed my mind, and Harvard Business School Dean John McArthur told me stories of Margaret Thatcher’s prodigious intelligence, pharmaceutical giant hostile takeovers, Roman mosaics spirited to Boston, and turning down billions from ethically clouded investment banker alums. Education, especially STEM studies for girls, matters. I have been fortunate to work in biotechnology, developing, alongside scientists, physicians, and dedicated, everyday folks, medicines based on antigens that cause allergic diseases and applying genomics to build personalized medicine while protecting patient privacy.

Dr. Wyle confronts today’s issues

Dr. Wyle is an internationally-respected biotechnology entrepreneur, President of the Massachusetts Women’s Forum, and supporter of wildlife research and protection in the United States, Canada, Africa, and Costa Rica. A mountaineer and conservationist, she is the author of the forthcoming book Live Big! about a 2003 British Columbia avalanche tragedy that buried a school group of 17, claimed the lives of seven children, and changed Canada’s relationship with its backcountry. Dr. Wyle speaks internationally and is a contributor to United States and Canadian media. She has served on numerous boards and champions conservation of animals and their habitat, healthcare improvement, and the empowerment of women and girls, especially in STEM fields and entrepreneurship.

Her writings confront today’s issues:

  • Venture capital-backed entrepreneurship in a dizzingly-fast world
  • Raising grounded children of grit and character
  • Intermingled joys of primal backcountry and vibrant city
  • Protecting our lands, their creatures and peoples
  • Living a powerful woman’s life
  • Committed one-foot-in-front-of-the-other perseverance to success

Dr. Wyle holds a B.S. in physics with a concentration in literature from Brown University, including study at Imperial College in London, Masters and Ph.D. degrees in medical physics from the Massachusetts Institute of Technology, and an M.B.A. from Harvard Business School where she was a Baker Scholar.

Dr. Wyle has founded two biotechnology companies, run global commercial operations, and managed corporate partnerships and financings including licensing, acquisitions, early financings and an IPO. She began her career at Westinghouse Electric Corporation and C.R. Bard creating new business ventures. While in business school, she worked in venture capital at Bessemer Venture Partners. She then joined ImmuLogic Pharmaceutical Corporation where she rose to the position of Vice President of Marketing and Business Development, and later Ontogeny (now Curis) as Chief Operating Officer.

As Founder and CEO of Computational Biology Corporation (acquired by Agilent), and Founder and Chairman of Ardais Corporation, Dr. Wyle pioneered new genomics-based businesses including Ardais’ clinical genomics library built in partnership with Duke University Medical Center, Harvard’s Beth Israel Deaconess Hospital, the University of Chicago Medical Center and Maine Medical Center. She is currently working with MIT collaborators to develop startup applications.

I have had the luck and pleasure of building our healthcare future for a living

Numerous organizations for which she has served as board member and advisor include the Massachusetts Institute of Technology; Brown University Medical School; the Brigham and Women’s Hospital Venture Advisory Board, The Brigham and Women’s Hospital Connors Center for Women’s Health; and MIT’s David H. Koch Institute for Integrative Cancer Research. As President of the Massachusetts Women’s Forum, she leads an organization of prominent women working to improve female leadership in all aspects of society, and mentors emerging female leaders and girls in STEM fields and entrepreneurship. Dr. Wyle is a Fellow of the Royal Canadian Geographical Society where she works to promote the exploration and knowledge of Canada’s wild places.

Each us of acting for the planet will save it

Dr. Wyle lives in Boston, Massachusetts with her husband, two daughters and two dogs. They own a home in Canmore, Alberta. The family’s work has included: sponsoring and engaging in field work advancing jaguar research in Costa Rica; supporting the First Nations-student body Exshaw School through book and clothing drives and building the first library on the Stoney Reserve in Morley; starting the Bow Valley Land Conservancy; and supporting Yellowstone to Yukon, an organization preserving and maintaining one of North America’s most important wildlife corridors from Yellowstone National Park to the Yukon Territory, the Churchill Northern Studies Research Centre, a leading center for polar bear research, The David Sheldrick Wildlife Trust, a sanctuary for elephants in Kenya, and wolf organizations.

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The Massachusetts Women’s Forum has been an important part of my life since I joined, and I am honored to be its President. Our women leaders represent all aspects of Massachusetts from business to hospitals to universities to major arts institutions and not for profits, and are making a difference everyday in Boston and the lives of our citizens. We run a mentoring event each spring and are proudly hosting the big International Women’s Forum conference this year in October. Please join us at the Gala on October 30 at the BCEC.